Stress Repair Mechanism
The SRM appears complex, but its underlying structure is simple and symmetrical.
Arrows represent the influence (direct and indirect) that one biological function or reaction brings to bear on another. The SRM is analogous to the older coagulation cascade concept, but it combines more recent research information with capillary gate theory and tissue repair theory to explain tissue repair, physiology and pathology as well as coagulation. It thus explains both tissue repair and hemodynamic physiology, which the older generation of stress researchers thought impossible.
The capillary gate component (red) corresponds to the intrinsic pathway of the coagulation cascade. The tissue repair component (blue) corresponds to the extrinsic pathway of the coagulation cascade. Both the SRM and the coagulation cascade generate thrombin (orange), plus soluble fibrin and insoluble fibrin. Inhibitory pathways appear in green. View a list of SRM tems and concepts here.